2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

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Chemical Name:2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester
CAS No.:852292-64-9
Molecular Formula:C₂₂H₂₀N₂O₈S
Molecular Weight:472.475
Hs Code.:

Synonyms:2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

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Chemical Property of 2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

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Technology Process of 2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

There total 5 articles about 2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 852292-52-5
4-methyl-N-[4-nitro-2-(3-oxo-prop-1-ynyl)-phenyl]-benzenesulfonamide

: 65434-72-2
2-(triphenylphosphoranylidene)succinic acid 1-ethyl ester

: 852292-64-9
2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Guidance literature:: In chloroform; toluene; at 20 ℃; for 48h;
DOI:10.1055/s-2005-863741

Reference yield:

: 852292-29-6
N-(2-iodo-4-nitrophenyl)-4-methylbenzenesulfonamide

: 852292-64-9
2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; CuI / (Ph₃P)2PdCl₂ / tetrahydrofuran; dimethylformamide

2: 100 percent / MnO₂ / CH₂Cl₂ / 8 h / 20 °C

3: 73 percent / toluene; CHCl₃ / 48 h / 20 °C

With manganese(IV) oxide; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 1: Sonogashira coupling / 3: Wittig reaction;
DOI:10.1055/s-2005-863741

Reference yield:

: 6293-83-0
2-iodo-4-nitrophenylamine

: 852292-64-9
2-[3-[5-Nitro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: Et₃N; CuI / (Ph₃P)2PdCl₂ / tetrahydrofuran; dimethylformamide

3: 100 percent / MnO₂ / CH₂Cl₂ / 8 h / 20 °C

4: 73 percent / toluene; CHCl₃ / 48 h / 20 °C

With pyridine; manganese(IV) oxide; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 2: Sonogashira coupling / 4: Wittig reaction;
DOI:10.1055/s-2005-863741