4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate

Base Information

• Chemical Name: 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate
• CAS No.: 1435263-75-4
• Molecular Formula: C₁₉H₁₃BrN₂O₄S
• Molecular Weight: 445.293
• Mol file: 1435263-75-4.mol

Synonyms:4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate

Chemical Property of 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate

There total 3 articles about 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-((6-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate (1435263-54-9) → 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate (1435263-75-4)

Guidance literature:

With iodine; potassium carbonate; In ethyl acetate; at 20 - 80 ℃; for 62h;

DOI:10.1039/c3ob40661j

Reference yield:

4-(2-hydroxyethyl)phenyl methanesulfonate (74447-38-4) → 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate (1435263-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 80 °C

2: isopropyl alcohol / 45 h / 87 °C

3: iodine; potassium carbonate / ethyl acetate / 62 h / 20 - 80 °C

With iodine; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; isopropyl alcohol; 2: |Pictet-Spengler Synthesis;

DOI:10.1039/c3ob40661j

Reference yield:

4-methylsulphonyloxyphenylacetaldehyde (74447-37-3) → 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate (1435263-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropyl alcohol / 45 h / 87 °C

2: iodine; potassium carbonate / ethyl acetate / 62 h / 20 - 80 °C

With iodine; potassium carbonate; In ethyl acetate; isopropyl alcohol; 1: |Pictet-Spengler Synthesis;

DOI:10.1039/c3ob40661j

upstream raw materials:

4-((6-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

4-(2-hydroxyethyl)phenyl methanesulfonate

4-methylsulphonyloxyphenylacetaldehyde

Downstream raw materials:

(6-bromo-9H-pyrido[3,4-b]indol-1-yl)(4-hydroxyphenyl)methanone

(6-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone