Propylene-bis-salicylamide

Base Information

• Chemical Name: Propylene-bis-salicylamide
• CAS No.: 24350-74-1
• Molecular Formula: C17H18 N2 O4
• Molecular Weight: 314.341
• NSC Number: 689436
• DSSTox Substance ID: DTXSID00947204
• Nikkaji Number: J314.074A
• Wikidata: Q82924964
• ChEMBL ID: CHEMBL426397
• Mol file: 24350-74-1.mol

Synonyms:Propylene-bis-salicylamide;NSC689436;CHEMBL426397;N,N'-Trimethylenedisalicylamide;Salicylamide, N,N'-trimethylenebis-;BRN 2671500;Benzamide, N,N'-1,3-propanediylbis(2-hydroxy-;N,N'-Bis(2-hydroxybenzoyl)-1,3-diaminopropane;2-hydroxy-N-[3-[(2-hydroxybenzoyl)amino]propyl]benzamide;24350-74-1;2-hydroxy-N-{3-[(2-hydroxybenzoyl)amino]propyl}benzamide;DTXSID00947204;1,3-bis(2-hydroxybenzamido)propane;BDBM50056894;NSC-689436;N,N'-Trimethylenebis(2-hydroxybenzamide);LS-144180;N,N''-(Propane-1,3-diyl)bis(2-hydroxybenzamide);N,N'-(Propane-1,3-diyl)bis(2-hydroxybenzene-1-carboximidic acid);(2-hydroxyphenyl)-N-(3-((2-hydroxyphenyl)carbonylamino)propyl)formamide

Chemical Property of Propylene-bis-salicylamide

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 314.12665706
• Heavy Atom Count: 23
• Complexity: 366

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NCCCNC(=O)C2=CC=CC=C2O)O

Technology Process of Propylene-bis-salicylamide

There total 7 articles about Propylene-bis-salicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Trimethylenediamine (109-76-2,54018-94-9) + 2-hydroxy-benzoic acid ethyl ester (118-61-6) → N,N'-bis(2-hydroxybenzoyl)-1,3-diaminopropane (24350-74-1)

Guidance literature:

at 110 ℃; for 5h;

DOI:10.1016/j.bmc.2009.10.037

Reference yield: 86.0%

phenyl Salicylate (118-55-8) + Trimethylenediamine (109-76-2,54018-94-9) → N,N'-bis(2-hydroxybenzoyl)-1,3-diaminopropane (24350-74-1)

Guidance literature:

at 150 ℃; for 1.5h;

Reference yield: 45.0%

Trimethylenediamine (109-76-2,54018-94-9) + salicylic acid pentafluorophenyl ester (187806-42-4) → N,N'-bis(2-hydroxybenzoyl)-1,3-diaminopropane (24350-74-1)

Guidance literature:

In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm960755+

upstream raw materials:

phenyl Salicylate

Trimethylenediamine

salicylic acid

salicylic acid pentafluorophenyl ester

Downstream raw materials:

1-amino-3-(2-hydroxybenzamide)propane

salicylic acid

N,N'-1,3-propanediyl-bis[2-(benzyl-carbamoyl-methoxy)-benzamide]

Refernces

• 1、 Cheng, Kui,Zheng, Qing-Zhong,Qian, Yong,Shi, Lei,Zhao, Jing,Zhu, Hai-Liang. "Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics". experimental part. p. 7861 - 7871. Retrieved 2010/03/24.
• 2、 Liu, Lilian Kao,Hsieh, Tsing-Pai,Kuo, Sung-Ming. "A Convenient Method for Preparing Some New Macrocyclic Diamides". . p. 309 - 312. Retrieved 2007/10/02.