3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile

Base Information

Chemical Name:3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile
CAS No.:373385-25-2
Molecular Formula:C₁₃H₁₈N₂O₂S
Molecular Weight:266.364
Hs Code.:

Synonyms:3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile

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Chemical Property of 3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile

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Technology Process of 3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile

There total 4 articles about 3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.9%

: 107-13-1,25014-41-9
acrylonitrile

: 373385-24-1
2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamine

: 373385-25-2
3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile

Guidance literature:: With p-benzoquinone; copper diacetate; at 110 ℃; for 4h;
DOI:10.1002/1099-0682(200109)2001:9<2427::AID-EJIC2427>3.0.CO;2-7

Reference yield:

: 20039-91-2
2-bromo-4-methyl-6-nitrophenol

: 373385-25-2
3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaOH / ethanol / 70 °C

1.2: 86.6 percent / tetrahydrofuran / 4 h / Heating

2.1: phenyllithium / tetrahydrofuran; hexane; diethyl ether / 1 h / -105 °C

2.2: 72.3 percent / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

3.1: 90.2 percent / hydrazine / Raney nickel / methanol / 1.5 h / Heating

4.1: 70.9 percent / quinone / Cu(OAc)2*H₂O / 4 h / 110 °C

With sodium hydroxide; phenyllithium; p-benzoquinone; hydrazine; copper diacetate; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane;
DOI:10.1002/1099-0682(200109)2001:9<2427::AID-EJIC2427>3.0.CO;2-7

Reference yield:

: 155877-01-3
1-Bromo-2-methoxymethoxy-5-methyl-3-nitro-benzene

: 373385-25-2
3-(2-methoxymethoxy-5-methyl-3-methylsulfanyl-phenylamino)-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenyllithium / tetrahydrofuran; hexane; diethyl ether / 1 h / -105 °C

1.2: 72.3 percent / tetrahydrofuran; hexane; diethyl ether / 0.5 h / -78 °C

2.1: 90.2 percent / hydrazine / Raney nickel / methanol / 1.5 h / Heating

3.1: 70.9 percent / quinone / Cu(OAc)2*H₂O / 4 h / 110 °C

With phenyllithium; p-benzoquinone; hydrazine; copper diacetate; nickel; In tetrahydrofuran; methanol; diethyl ether; hexane;
DOI:10.1002/1099-0682(200109)2001:9<2427::AID-EJIC2427>3.0.CO;2-7