tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

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Chemical Name:tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate
CAS No.:1604811-92-8
Molecular Formula:C₃₇H₃₃ClN₆O₅S
Molecular Weight:709.225
Hs Code.:

Synonyms:tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

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Chemical Property of tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

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Technology Process of tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

There total 7 articles about tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882562-40-5
3-(2,5-dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole

: tert-butyl 4-((3-aminophenyl)(methyl)carbamoyl)phenylcarbamate

: 1604811-92-8
tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

Guidance literature:: With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In isopropyl alcohol; toluene; at 90 ℃; for 72h;

Reference yield:

: 113261-00-0
benzyl (3-aminophenyl)carbamate

: 1604811-92-8
tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 20 °C

2.1: lithium aluminium tetrahydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

2.2: 4 h / 20 °C

3.1: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

4.1: 2-(Dimethylamino)pyridine / dichloromethane; N,N-dimethyl-formamide / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 4 h / 760.05 Torr

6.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 72 h / 90 °C

With pyridine; methanol; 2-(Dimethylamino)pyridine; potassium phosphate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;

Reference yield:

: 108-45-2,64554-26-3,76583-20-5
m-phenylenediamine

: 1604811-92-8
tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: pyridine / dichloromethane / 20 °C

3.1: lithium aluminium tetrahydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

3.2: 4 h / 20 °C

4.1: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

5.1: 2-(Dimethylamino)pyridine / dichloromethane; N,N-dimethyl-formamide / 20 °C

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 4 h / 760.05 Torr

7.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 72 h / 90 °C

With pyridine; methanol; 2-(Dimethylamino)pyridine; potassium phosphate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; palladium diacetate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;