4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide

Base Information

Chemical Name:4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide
CAS No.:1604811-94-0
Molecular Formula:C₃₂H₂₅ClN₆O₃S
Molecular Weight:609.108
Hs Code.:

Synonyms:4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide

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Chemical Property of 4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide

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Technology Process of 4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide

There total 9 articles about 4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1604811-92-8
tert-butyl 4-((3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)(methyl)carbamoyl)phenylcarbamate

: 1604811-94-0
4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 113261-00-0
benzyl (3-aminophenyl)carbamate

: 1604811-94-0
4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 20 °C

2.1: lithium aluminium tetrahydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

2.2: 4 h / 20 °C

3.1: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

4.1: 2-(Dimethylamino)pyridine / dichloromethane; N,N-dimethyl-formamide / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 4 h / 760.05 Torr

6.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 72 h / 90 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With pyridine; methanol; 2-(Dimethylamino)pyridine; potassium phosphate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;

Reference yield:

: 882562-40-5
3-(2,5-dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole

: 1604811-94-0
4-amino-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / toluene; isopropyl alcohol / 72 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane; isopropyl alcohol; toluene;