N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide

Base Information

Chemical Name:N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide
CAS No.:1445901-81-4
Molecular Formula:C₂₃H₂₆Cl₂FN₃O₃S
Molecular Weight:514.448
Hs Code.:

Synonyms:N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide

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Technology Process of N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide

There total 4 articles about N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 705-21-5
3,5-dichlorobenzensulfonyl chloride

: 1445902-93-1
1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone

: 1445901-81-4
N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1445902-92-0
4-(4-acetylpiperazin-1-yl)-2-fluorobenzaldehyde

: 1445901-81-4
N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 23 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 23 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml500420y

Reference yield:

: 13889-98-0
N-acetylpiperidine

: 1445901-81-4
N-(4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl)-3,5-dichloro-N-cyclobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; ruphos; sodium t-butanolate / 1,4-dioxane / 100 °C

1.2: 23 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 23 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 23 °C

With palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; ruphos; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; 1.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/ml500420y