1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone
CAS No.:1445902-93-1
Molecular Formula:C₁₇H₂₄FN₃O
Molecular Weight:305.395
Hs Code.:

Synonyms:1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone

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Chemical Property of 1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone

Chemical Property:

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Technology Process of 1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone

There total 2 articles about 1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13889-98-0
N-acetylpiperidine

: 1445902-93-1
1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium diacetate; ruphos; sodium t-butanolate / 1,4-dioxane / 100 °C

1.2: 23 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 23 °C

With palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane; 1,2-dichloro-ethane; 1.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/ml500420y

Reference yield:

: 439814-87-6
4-bromo-1-(dimethoxymethyl)-2-fluorobenzene

: 1445902-93-1
1-(4-(4-((cyclobutylamino)methyl)-3-fluorophenyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium diacetate; ruphos; sodium t-butanolate / 1,4-dioxane / 100 °C

1.2: 23 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 23 °C

With palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane; 1,2-dichloro-ethane; 1.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/ml500420y