N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Base Information

Chemical Name:N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide
CAS No.:1429204-51-2
Molecular Formula:C₂₄H₂₁Cl₂F₃N₂O₃
Molecular Weight:513.344
Hs Code.:

Synonyms:N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

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Chemical Property of N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

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Technology Process of N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

There total 8 articles about N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1429204-50-1
C₁₇H₁₇BrCl₂N₂O₃

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1429204-51-2
N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Guidance literature:: With sodium carbonate; In 1,2-dimethoxyethane; at 110 ℃; for 6h; Microwave irradiation;

Reference yield:

: 130879-43-5
3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester

: 1429204-51-2
N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C

2: lithium hydroxide / water; tetrahydrofuran / 50 °C

3: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

4: triethylamine / dichloromethane / 20 °C

5: sodium carbonate / 1,2-dimethoxyethane / 6 h / 110 °C / Microwave irradiation

With N-Bromosuccinimide; oxalyl dichloride; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1429204-40-9
ethyl 6-bromo-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

: 1429204-51-2
N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / water; tetrahydrofuran / 50 °C

2: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

3: triethylamine / dichloromethane / 20 °C

4: sodium carbonate / 1,2-dimethoxyethane / 6 h / 110 °C / Microwave irradiation

With oxalyl dichloride; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;