N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Base Information

Chemical Name:N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide
CAS No.:1429201-54-6
Molecular Formula:C₂₃H₁₉Cl₂F₃N₂O₃
Molecular Weight:499.317
Hs Code.:

Synonyms:N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

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Chemical Property of N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

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Technology Process of N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

There total 9 articles about N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1429204-51-2
N-(3-(3,4-dichlorophenyl)propyl)-3-methoxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

: 1429201-54-6
N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Guidance literature:: With boron tribromide dimethyl sulfide complex; In dichloromethane; at 20 ℃;

Reference yield:

: 130879-43-5
3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester

: 1429201-54-6
N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C

2: lithium hydroxide / water; tetrahydrofuran / 50 °C

3: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

4: triethylamine / dichloromethane / 20 °C

5: sodium carbonate / 1,2-dimethoxyethane / 6 h / 110 °C / Microwave irradiation

6: boron tribromide dimethyl sulfide complex / dichloromethane / 20 °C

With N-Bromosuccinimide; oxalyl dichloride; sodium carbonate; triethylamine; boron tribromide dimethyl sulfide complex; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1429204-40-9
ethyl 6-bromo-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

: 1429201-54-6
N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-6-(3(trifluoromethyl)phenyl)-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide / water; tetrahydrofuran / 50 °C

2: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

3: triethylamine / dichloromethane / 20 °C

4: sodium carbonate / 1,2-dimethoxyethane / 6 h / 110 °C / Microwave irradiation

5: boron tribromide dimethyl sulfide complex / dichloromethane / 20 °C

With oxalyl dichloride; sodium carbonate; triethylamine; boron tribromide dimethyl sulfide complex; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;