1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

Base Information

Chemical Name:1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea
CAS No.:1455033-39-2
Molecular Formula:C₂₃H₂₈FN₅O
Molecular Weight:409.507
Hs Code.:

Synonyms:1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

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Chemical Property of 1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

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Technology Process of 1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

There total 13 articles about 1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1455037-46-3
1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)phenyl)urea

: 1455033-39-2
1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 3h;

Reference yield:

: 1455036-62-0
prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate

: 1455033-39-2
1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 80 °C

2: trifluoroacetic acid / 3 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In 1,4-dioxane;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1455033-39-2
1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dimethyl sulfoxide / 20 °C

2: trifluoroacetic acid / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / dichloromethane / 20 °C

5: potassium hydroxide / ethanol / 1 h / 60 °C

6: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 170 - 185 °C / Inert atmosphere

7: sodium hydrogencarbonate / ethyl acetate / 2 h / 20 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 80 °C

9: trifluoroacetic acid / 3 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; 7: |Schotten-Baumann Reaction;