prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate

Base Information

• Chemical Name: prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate
• CAS No.: 1455036-62-0
• Molecular Formula: C₂₈H₂₇FN₄O₃
• Molecular Weight: 486.546
• Mol file: 1455036-62-0.mol

Synonyms:prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate

Chemical Property of prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate

There total 11 articles about prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Isopropenyl chloroformate (57933-83-2) + 3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl[1,6]naphthyridin-7-amine (1455036-08-4) → prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate (1455036-62-0)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

ethyl 4,6-dichloronicotinate (40296-46-6) → prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate (1455036-62-0)

Guidance literature:

Multi-step reaction with 7 steps

1: triethylamine / dimethyl sulfoxide / 20 °C

2: trifluoroacetic acid / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / dichloromethane / 20 °C

5: potassium hydroxide / ethanol / 1 h / 60 °C

6: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 170 - 185 °C / Inert atmosphere

7: sodium hydrogencarbonate / ethyl acetate / 2 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; 7: |Schotten-Baumann Reaction;

Reference yield:

ethyl 6-chloro-4-[(4-methoxyphenyl)methylamino]pyridine-3-carboxylate (1391740-89-8) → prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)phenyl)carbamate (1455036-62-0)

Guidance literature:

Multi-step reaction with 6 steps

1: trifluoroacetic acid / 50 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: manganese(IV) oxide / dichloromethane / 20 °C

4: potassium hydroxide / ethanol / 1 h / 60 °C

5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 170 - 185 °C / Inert atmosphere

6: sodium hydrogencarbonate / ethyl acetate / 2 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; ethyl acetate; 6: |Schotten-Baumann Reaction;

upstream raw materials:

ethyl 4,6-dichloronicotinate

ethyl 6-chloro-4-[(4-methoxyphenyl)methylamino]pyridine-3-carboxylate

ethyl 4-amino-6-chloropyridine-3-carboxylate

(4-amino-6-chloropyridin-3-yl)methanol

Downstream raw materials:

1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea hydrochloride

1-(3,3-dimethylbutyl)-3-(2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)phenyl)urea