4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one

Base Information

Chemical Name:4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one
CAS No.:1429874-07-6
Molecular Formula:C₁₇H₁₉F₃N₂O₅S
Molecular Weight:420.409
Hs Code.:

Synonyms:4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one

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Chemical Property of 4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one

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Technology Process of 4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one

There total 9 articles about 4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1429874-08-7
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-1H-pyridazine-3,6-dione

: 107-08-4
1-iodo-propane

: 1429874-07-6
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 77541-59-4
5-chloro-4-methoxy-2-methyl-3(2H)-pyridazinone

: 1429874-07-6
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

2: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

3: dihydrogen peroxide; acetic acid / water / 55 °C

4: sulfuric acid; nitric acid / 5.9 h / 0 - 50 °C

5: ammonium formate; 10 wt% Pd(OH)2 on carbon / ethanol / 1 h / 80 °C

6: sodium nitrite; sulfuric acid; acetic acid / 0.67 h / 0 - 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; 10 wt% Pd(OH)2 on carbon; dihydrogen peroxide; nitric acid; ammonium formate; potassium acetate; potassium carbonate; acetic acid; cesium fluoride; sodium nitrite; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1429874-07-6
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-6-propoxy-pyridazin-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1,4-dioxane / 1 h / 20 °C

2: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

4: dihydrogen peroxide; acetic acid / water / 55 °C

5: sulfuric acid; nitric acid / 5.9 h / 0 - 50 °C

6: ammonium formate; 10 wt% Pd(OH)2 on carbon / ethanol / 1 h / 80 °C

7: sodium nitrite; sulfuric acid; acetic acid / 0.67 h / 0 - 20 °C

8: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; 10 wt% Pd(OH)2 on carbon; dihydrogen peroxide; nitric acid; ammonium formate; potassium acetate; potassium carbonate; acetic acid; cesium fluoride; sodium nitrite; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;