(S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate

Base Information

Chemical Name:(S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate
CAS No.:1262215-23-5
Molecular Formula:C₃₀H₃₁NO₄
Molecular Weight:469.58
Hs Code.:

Synonyms:(S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate

Chemical Property:

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Technology Process of (S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate

There total 6 articles about (S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1262215-22-4
(2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

: 1262215-23-5
(S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate

Guidance literature:: With sodium periodate; sodium hydrogencarbonate; In methanol; water; at 25 ℃; for 2h; optical yield given as %ee;
DOI:10.1021/jo102272h

Reference yield:

: 80493-48-7
ethyl α-phenylselenopropenoate

: 1262215-23-5
(S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate

Guidance literature:: Multi-step reaction with 4 steps

1: Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; potassium hydroxide / dichloromethane; water / 1 h / -20 °C / Michael addition

2: hydrogenchloride; water / tetrahydrofuran / 0.3 h / 25 °C

3: potassium phosphate; lead acetate / acetonitrile / 5 h / 25 °C

4: sodium periodate; sodium hydrogencarbonate / methanol; water / 2 h / 25 °C

With hydrogenchloride; potassium phosphate; sodium periodate; Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; water; lead acetate; sodium hydrogencarbonate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo102272h

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 1262215-23-5
(S,E)-5-tert-butyl 1-ethyl 4-(9-phenyl-9H-fluoren-9-ylamino)pent-2-enedioate

Guidance literature:: Multi-step reaction with 5 steps

1: zinc(II) chloride / dichloromethane / 3 °C

2: Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; potassium hydroxide / dichloromethane; water / 1 h / -20 °C / Michael addition

3: hydrogenchloride; water / tetrahydrofuran / 0.3 h / 25 °C

4: potassium phosphate; lead acetate / acetonitrile / 5 h / 25 °C

5: sodium periodate; sodium hydrogencarbonate / methanol; water / 2 h / 25 °C

With hydrogenchloride; potassium phosphate; sodium periodate; Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; water; lead acetate; sodium hydrogencarbonate; potassium hydroxide; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo102272h