(2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

Base Information

Chemical Name:(2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate
CAS No.:1262215-22-4
Molecular Formula:C₃₆H₃₇NO₄Se
Molecular Weight:626.654
Hs Code.:

Synonyms:(2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

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Chemical Property of (2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

Chemical Property:

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Technology Process of (2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

There total 4 articles about (2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1262215-21-3
(2S)-1-tert-butyl 5-ethyl 2-amino-4-(phenylselanyl)pentanedioate

: 55135-66-5
9-bromo-9-phenyl-9H-fluorene

: 1262215-22-4
(2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

Guidance literature:: With potassium phosphate; lead acetate; In acetonitrile; at 25 ℃; for 5h;
DOI:10.1021/jo102272h

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 1262215-22-4
(2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: zinc(II) chloride / dichloromethane / 3 °C

2: Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; potassium hydroxide / dichloromethane; water / 1 h / -20 °C / Michael addition

3: hydrogenchloride; water / tetrahydrofuran / 0.3 h / 25 °C

4: potassium phosphate; lead acetate / acetonitrile / 5 h / 25 °C

With hydrogenchloride; potassium phosphate; Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; water; lead acetate; potassium hydroxide; zinc(II) chloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jo102272h

Reference yield:

: 80493-48-7
ethyl α-phenylselenopropenoate

: 1262215-22-4
(2S)-1-tert-butyl 5-ethyl 2-(9-phenyl-9H-fluoren-9-ylamino)-4-(phenylselanyl)pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; potassium hydroxide / dichloromethane; water / 1 h / -20 °C / Michael addition

2: hydrogenchloride; water / tetrahydrofuran / 0.3 h / 25 °C

3: potassium phosphate; lead acetate / acetonitrile / 5 h / 25 °C

With hydrogenchloride; potassium phosphate; Br^(1-)*C₃₇H₃₉N₂O⁽¹⁺⁾; water; lead acetate; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jo102272h