Technology Process of (2S,3S,4R)-1-tert-butyl 5-ethyl 3,4-dihydroxy-2-(9-phenyl-9H-fluoren-9-ylamino)pentanedioate
There total 7 articles about (2S,3S,4R)-1-tert-butyl 5-ethyl 3,4-dihydroxy-2-(9-phenyl-9H-fluoren-9-ylamino)pentanedioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium osmate(VI) dihydrate; methanesulfonamide; potassium carbonate; (1R)-((1S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl 4-chlorobenzoate; potassium hexacyanoferrate(III);
In
water; tert-butyl alcohol;
at 0 ℃;
for 3.5h;
optical yield given as %de;
diastereoselective reaction;
DOI:10.1021/jo102272h
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Br(1-)*C37H39N2O(1+); potassium hydroxide / dichloromethane; water / 1 h / -20 °C / Michael addition
2: hydrogenchloride; water / tetrahydrofuran / 0.3 h / 25 °C
3: potassium phosphate; lead acetate / acetonitrile / 5 h / 25 °C
4: sodium periodate; sodium hydrogencarbonate / methanol; water / 2 h / 25 °C
5: potassium osmate(VI) dihydrate; methanesulfonamide; potassium carbonate; (1R)-((1S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl 4-chlorobenzoate; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 3.5 h / 0 °C
With
hydrogenchloride; potassium osmate(VI) dihydrate; potassium phosphate; sodium periodate; methanesulfonamide; Br(1-)*C37H39N2O(1+); water; lead acetate; sodium hydrogencarbonate; potassium carbonate; (1R)-((1S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl 4-chlorobenzoate; potassium hydroxide; potassium hexacyanoferrate(III);
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo102272h
- Guidance literature:
-
Multi-step reaction with 6 steps
1: zinc(II) chloride / dichloromethane / 3 °C
2: Br(1-)*C37H39N2O(1+); potassium hydroxide / dichloromethane; water / 1 h / -20 °C / Michael addition
3: hydrogenchloride; water / tetrahydrofuran / 0.3 h / 25 °C
4: potassium phosphate; lead acetate / acetonitrile / 5 h / 25 °C
5: sodium periodate; sodium hydrogencarbonate / methanol; water / 2 h / 25 °C
6: potassium osmate(VI) dihydrate; methanesulfonamide; potassium carbonate; (1R)-((1S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl 4-chlorobenzoate; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 3.5 h / 0 °C
With
hydrogenchloride; potassium osmate(VI) dihydrate; potassium phosphate; sodium periodate; methanesulfonamide; Br(1-)*C37H39N2O(1+); water; lead acetate; sodium hydrogencarbonate; potassium carbonate; (1R)-((1S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl 4-chlorobenzoate; potassium hydroxide; zinc(II) chloride; potassium hexacyanoferrate(III);
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo102272h
