4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

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Chemical Name:4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid
CAS No.:1448687-67-9
Molecular Formula:C₂₁H₁₆N₄O₃S
Molecular Weight:404.449
Hs Code.:

Synonyms:4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

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Chemical Property of 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

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Technology Process of 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

There total 2 articles about 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1448687-66-8
ethyl 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoate

: 1448687-67-9
4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; at 20 ℃;
DOI:10.1016/j.ejmech.2013.05.012

Reference yield:

: 1430822-01-7
3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one

: 1448687-67-9
4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux

2: potassium hydroxide / ethanol; water / 20 °C

With potassium carbonate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; 1: |Dimroth Rearrangement;
DOI:10.1016/j.ejmech.2013.05.012

Reference yield: 70.0%

: 1448687-67-9
4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

: 51-45-6
histamine

: 1448687-68-0
N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

Guidance literature:: 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h; Inert atmosphere;

histamine; In 1,4-dioxane; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.012