N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

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Chemical Name:N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide
CAS No.:1448687-68-0
Molecular Formula:C₂₆H₂₃N₇O₂S
Molecular Weight:497.58
Hs Code.:

Synonyms:N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

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Chemical Property of N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

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Technology Process of N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

There total 3 articles about N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1448687-67-9
4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid

: 51-45-6
histamine

: 1448687-68-0
N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

Guidance literature:: 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h; Inert atmosphere;

histamine; In 1,4-dioxane; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.012

Reference yield:

: 1430822-01-7
3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one

: 1448687-68-0
N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux

2.1: potassium hydroxide / ethanol; water / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 12 h / 50 °C / Inert atmosphere

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 1.1: |Dimroth Rearrangement;
DOI:10.1016/j.ejmech.2013.05.012

Reference yield:

: 1448687-66-8
ethyl 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoate

: 1448687-68-0
N-(2-(1H-imidazol-4-yl)ethyl)-4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol; water / 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 50 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.ejmech.2013.05.012