trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate

Base Information

Chemical Name:trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate
CAS No.:1338447-23-6
Molecular Formula:C₃₉H₄₄F₆O₄
Molecular Weight:690.766
Hs Code.:

Synonyms:trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate

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Chemical Property of trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate

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Technology Process of trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate

There total 13 articles about trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.5%

: 1338448-99-9
trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)-cyclohexylcarboxylic acid

: trans-4-(4'-hexyloxy-2,3-difluorophenyl)-cyclohexanol

: 1338447-23-6
trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 25 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1122-58-3
dmap

: 1,3-Dicyclohexylcarbodiimide (DCC)

4-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl: 1241535-57-8
4-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl

: 1338448-99-9
trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)-cyclohexylcarboxylic acid

: 1338447-23-6
trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate

Guidance literature:: In water; toluene;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1338447-23-6
trans-4-(2,3-difluoro-4-hexyloxyphenyl)cyclohexyl trans-4-(4'-ethoxy-2,2',3,3'-tetrafluoro-1,1'-biphenyl-4-yl)cyclohexylcarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane; hexane / 2 h / -74 - -70 °C / Inert atmosphere

1.2: 8 h / -75 - -70 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

2.2: 20 °C

3.1: formic acid / toluene / 2 h / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C

5.1: dicyclohexyl-carbodiimide; dmap / toluene / 20 h / 25 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; formic acid; sec.-butyllithium; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; cyclohexane; toluene;