N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide

Base Information

Chemical Name:N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide
CAS No.:1108999-75-2
Molecular Formula:C₂₆H₂₈ClN₅O₃S
Molecular Weight:526.059
Hs Code.:

Synonyms:N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide

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Chemical Property of N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide

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Technology Process of N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide

There total 3 articles about N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 368869-91-4
6-phenoxypyridine-3-sulfonyl chloride

: 1108999-74-1
N-ethyl-N-[2-(7-chloro-4-quinolyl)aminoethyl]-1,2-diaminoethane

: 1108999-75-2
N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2008.11.009

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1108999-75-2
N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 6 h / 110 °C / Inert atmosphere

1.2: 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C

2.2: 24 h / 25 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 °C

4.1: hydrogenchloride / methanol; water / 20 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 5407-57-8
N-(7-chloroquinolin-4-yl)ethylenediamine

: 1108999-75-2
N-[2-{N'-2-(7-chloro-4-quinolyl)aminoethyl-N''-ethyl}aminoethyl]-2-phenoxy-5-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C

1.2: 24 h / 25 °C

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 °C

3.1: hydrogenchloride / methanol; water / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;