2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Base Information

Chemical Name:2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide
CAS No.:159780-56-0
Molecular Formula:C₂₉H₃₉F₃N₂O₇Si
Molecular Weight:612.719
Hs Code.:

2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Synonyms:2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Chemical Property of 2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Technology Process of 2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

There total 10 articles about 2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 159780-55-9
2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

: 159780-56-0
2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: With lithium iodide; In pyridine; for 14h; Heating;
DOI:10.1021/jm950684z

Reference yield:

: 159780-00-4
2-[3-(4-Methoxybenzyl)-2,4,8-trioxo-6-phenyl-1,2,3,4,7,8-hexahydro-pyrido-[3,4-d]pyrimidin-7-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

: 159780-56-0
2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: With lithium iodide; In pyridine;

Reference yield:

: 617-35-6
2-oxo-propionic acid ethyl ester

: 159780-56-0
2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / ZnCl₂, Ac₂O / 2 h / Heating

2: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h

3: 48 percent / 24 h / 120 °C / 1 Torr

4: 96 percent / LiI / pyridine / 14 h / Heating

With acetic anhydride; sodium hydride; zinc(II) chloride; lithium iodide; In pyridine;
DOI:10.1021/jm950684z