2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Base Information

Chemical Name:2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide
CAS No.:159780-55-9
Molecular Formula:C₃₀H₄₁F₃N₂O₇Si
Molecular Weight:626.745
Hs Code.:

2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Synonyms:2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Chemical Property of 2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Technology Process of 2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

There total 8 articles about 2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 159780-14-0
2-amino-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropyl>acetamide

: dimethyl <2-(ethoxycarbonyl)-3-(dimethylamino)-3-phenyl-2-propenylidene>malonate

: 159780-55-9
2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: at 120 ℃; for 24h; under 1 Torr;
DOI:10.1021/jm950684z

Reference yield:

: 159780-12-8
2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

: 159780-55-9
2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine / tetrahydrofuran / 16 h / Ambient temperature

2: 81 percent / N₂H₄*H₂O / 3 h / Heating

3: 48 percent / 24 h / 120 °C / 1 Torr

With 2,6-dimethylpyridine; hydrazine hydrate; In tetrahydrofuran;
DOI:10.1021/jm950684z

Reference yield:

: 611-74-5
N,N-dimethylbenzamide

: 159780-55-9
2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h

3: 48 percent / 24 h / 120 °C / 1 Torr

With oxalyl dichloride; sodium hydride; In dichloromethane;
DOI:10.1021/jm950684z