4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

Base Information

• Chemical Name: 4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one
• CAS No.: 1616290-27-7
• Molecular Formula: C₂₈H₃₁BrN₂O₄
• Molecular Weight: 539.469
• Mol file: 1616290-27-7.mol

Synonyms:4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

Chemical Property of 4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

There total 15 articles about 4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-propane (75-30-9) + C26H27BrN2O6S → 4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (1616290-27-7)

Guidance literature:

C₂₆H₂₇BrN₂O₆S; With ethyl-2-hexylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 20 ℃;

2-iodo-propane; With caesium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl acetamide; at 75 ℃; for 1h;

Reference yield:

2-hydroxy-4,6-dimethyl-3-carbonitrile (769-28-8,70254-47-6) → 4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (1616290-27-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: silver(l) oxide / toluene / 20 h / 110 °C

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3.1: methanol / 1 h / 20 °C

4.1: methanol; sodium cyanoborohydride / 0 - 20 °C

5.1: triethylamine / dichloromethane / 18 h / 20 °C

6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

7.1: phosphoric acid / dichloromethane / 4 h / 20 °C

8.1: sodium hydroxide / water; methanol / 1 h / 120 °C / Microwave irradiation

9.1: ethyl-2-hexylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 20 °C

9.2: 1 h / 75 °C

With methanol; ethyl-2-hexylamine; di-isopropyl azodicarboxylate; phosphoric acid; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde (721959-71-3) → 4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (1616290-27-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: methanol / 1 h / 20 °C

2.1: methanol; sodium cyanoborohydride / 0 - 20 °C

3.1: triethylamine / dichloromethane / 18 h / 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

5.1: phosphoric acid / dichloromethane / 4 h / 20 °C

6.1: sodium hydroxide / water; methanol / 1 h / 120 °C / Microwave irradiation

7.1: ethyl-2-hexylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 20 °C

7.2: 1 h / 75 °C

With methanol; ethyl-2-hexylamine; di-isopropyl azodicarboxylate; phosphoric acid; sodium cyanoborohydride; triethylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

2-hydroxy-4,6-dimethyl-3-carbonitrile

2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile

2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol

Downstream raw materials:

4-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-6-methyl-9-[2-(methylamino)pyrimidin-5-yl]-7-(propan-2-yloxy)-3,4-dihydro-1,4-benzoxazepin-5(2H)-one