3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

Base Information

Chemical Name:3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide
CAS No.:1095005-87-0
Molecular Formula:C₃₁H₃₀BrFN₄O₃
Molecular Weight:605.507
Hs Code.:

Synonyms:3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

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Chemical Property of 3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

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Technology Process of 3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

There total 18 articles about 3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095005-86-9
3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methyl-benzoic acid, ethyl ester

: 765-30-0
Cyclopropylamine

: 1095005-87-0
3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

Guidance literature:: 3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methyl-benzoic acid, ethyl ester; Cyclopropylamine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 - 75 ℃; for 16.1667h;

With hydrogenchloride; water; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

: 1095006-02-2
3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methyl-benzoic acid, methyl ester

: 765-30-0
Cyclopropylamine

: 1095005-87-0
3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at 25 ℃; for 1.16667h; Product distribution / selectivity;

Reference yield:

: 201849-17-4
1-bromo-2-chloro-5-fluoro-4-methylbenzene

: 1095005-87-0
3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 27 h / 90 °C

2: sodium hydroxide; water / methanol / 1 h / 25 °C

3: sulfuric acid; potassium nitrate / 1.17 h / 0 - 50 °C

4: methanol / 22 h / 20 - 50 °C

5: ammonium formate / 5%-palladium/activated carbon / ethanol / 62 h / 75 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22 h / Heating / reflux

7: dichloromethane; N,N-dimethyl-formamide / 16.25 h / 0 - 20 °C / Heating / reflux

8: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 10 h / 100 °C

9: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 25 °C

With sodium hydroxide; sulfuric acid; water; isopropylmagnesium chloride; ammonium formate; potassium nitrate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;