N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Base Information

Chemical Name:N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide
CAS No.:1095005-88-1
Molecular Formula:C₂₄H₂₅FN₄O₃
Molecular Weight:436.486
Hs Code.:

Synonyms:N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

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Chemical Property of N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

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Technology Process of N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

There total 20 articles about N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095005-87-0
3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

: 1095005-88-1
N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; at 75 ℃; for 2h;

Reference yield:

: 13524-76-0
2,3-Dihydro-3,3-dimethylbenzofuran-2-one

: 1095005-88-1
N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia / methanol / 16 h / 25 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

3.1: bis-[(trifluoroacetoxy)iodo]benzene / water; acetonitrile / 60 h / 20 °C

3.2: 0 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 10 h / 100 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 25 °C

6.1: ammonium formate / palladium 10% on activated carbon / 2 h / 75 °C

With ammonia; isopropylmagnesium chloride; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1095005-91-6
α,α-dimethyl-2-(phenylmethoxy)-benzeneacetamide

: 1095005-88-1
N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-[(trifluoroacetoxy)iodo]benzene / water; acetonitrile / 60 h / 20 °C

1.2: 0 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 10 h / 100 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 25 °C

4.1: ammonium formate / palladium 10% on activated carbon / 2 h / 75 °C

With isopropylmagnesium chloride; ammonium formate; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;