(R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

Base Information

• Chemical Name: (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate
• CAS No.: 1196091-14-1
• Molecular Formula: CHO₂*C₃₁H₄₀NO₃
• Molecular Weight: 519.681
• Mol file: 1196091-14-1.mol

Synonyms:(R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

Chemical Property of (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

There total 10 articles about (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydro-5-(2-bromoethyl)benzofuran (127264-14-6) + formic acid (64-18-6) + 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (1026791-31-0) → (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate (1196091-14-1)

Guidance literature:

2,3-dihydro-5-(2-bromoethyl)benzofuran; 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester; In acetonitrile; at 20 ℃; for 22h;

formic acid; In acetonitrile;

Reference yield:

cycloheptyl(phenyl)methanone (6004-52-0) → (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate (1196091-14-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / 1 h / 0 °C

1.2: Reflux

2.1: water / silver nitrate / 1,4-dioxane / 4.5 h / 75 °C

3.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

4.1: toluene / 0.5 h / Reflux

4.2: Inert atmosphere; Reflux

5.1: acetonitrile / 22 h / 20 °C

With sulfuryl dichloride; water; trimethylsilyldiazomethane; silver nitrate; In 1,4-dioxane; toluene; acetonitrile;

Reference yield:

cycloheptanone (502-42-1) → (R)-1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate (1196091-14-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

1.2: 0.17 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 60 °C

2.2: 60 °C / Reflux

3.1: potassium; sodium / diethyl ether / 20 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

3.3: pH 7

4.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

5.1: toluene / 0.5 h / Reflux

5.2: Inert atmosphere; Reflux

6.1: acetonitrile / 22 h / 20 °C

With iodine; sodium; potassium; sodium hydride; magnesium; trimethylsilyldiazomethane; In tetrahydrofuran; diethyl ether; toluene; acetonitrile; mineral oil;

upstream raw materials:

2,3-dihydro-5-(2-bromoethyl)benzofuran

formic acid

1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

cycloheptanone