Technology Process of (1S,9R,12R)-3-Hydroxy-12-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-4,6-dimethoxy-5-methyl-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one
There total 16 articles about (1S,9R,12R)-3-Hydroxy-12-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-4,6-dimethoxy-5-methyl-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2,4,6-trien-10-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
Raney Ni-W2;
In
ethanol;
at 100 ℃;
under 51714.8 Torr;
DOI:10.1021/ja00382a042
- Guidance literature:
-
Multi-step reaction with 10 steps
2: n-butyllithium / -78 °C
3: tetrahydrofuran / -78 deg C -> room temperature
4: 3N HCl, water / tetrahydrofuran / Ambient temperature
5: 83 percent / 3N NaOH / methanol / Ambient temperature
6: 83 percent / DCC / CH2Cl2 / Ambient temperature
7: 98 percent / pyridine / 60 °C
8: 1.) ozone, 2.) dimethyl disulfide / 1.) 50percent methanol, CH2Cl2, -78 deg C
9: 1.) DBU, 2.) formic acid / 1.) CH2Cl", 0 deg C, 2.) 60 deg C, 20 min
10: hydrogen / Raney Ni-W2 / ethanol / 100 °C / 51714.8 Torr
With
pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; formic acid; Dimethyldisulphide; water; hydrogen; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide;
Raney Ni-W2;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ja00382a042
- Guidance literature:
-
Multi-step reaction with 9 steps
1: n-butyllithium / -78 °C
2: tetrahydrofuran / -78 deg C -> room temperature
3: 3N HCl, water / tetrahydrofuran / Ambient temperature
4: 83 percent / 3N NaOH / methanol / Ambient temperature
5: 83 percent / DCC / CH2Cl2 / Ambient temperature
6: 98 percent / pyridine / 60 °C
7: 1.) ozone, 2.) dimethyl disulfide / 1.) 50percent methanol, CH2Cl2, -78 deg C
8: 1.) DBU, 2.) formic acid / 1.) CH2Cl", 0 deg C, 2.) 60 deg C, 20 min
9: hydrogen / Raney Ni-W2 / ethanol / 100 °C / 51714.8 Torr
With
pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; formic acid; Dimethyldisulphide; water; hydrogen; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide;
Raney Ni-W2;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ja00382a042
![(1R,9S)-3-Benzyloxy-12-[1-(5-benzyloxy-2,4-dimethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-4,6-dimethoxy-5-methyl-10-oxo-11,13-diaza-tricyclo[7.3.1.0<sup>2,7</sup>]trideca-2,4,6-triene-13-carboxylic acid benzyl ester](/Databaselist/images/loading.webp)
