5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

Base Information

Chemical Name:5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine
CAS No.:1401349-05-0
Molecular Formula:C₃₆H₂₈ClN₅O₃S₂
Molecular Weight:678.235
Hs Code.:

Synonyms:5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

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Chemical Property of 5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

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Technology Process of 5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

There total 6 articles about 5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1401349-04-9
5-(3-(6-chloropyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

: 1679-18-1
4-Chlorophenylboronic acid

: 1401349-05-0
5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 105 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1401348-60-4
2-(1H-indol-5-yl)-5-(methylthio)-1,3,4-thiadiazole

: 1401349-05-0
5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C

3: sodium tungstate; dihydrogen peroxide / water; acetic acid / 72 h / 20 °C

4: 1,4-dioxane / 20 - 100 °C

5: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / 1,4-dioxane; water / 0.5 h / 105 °C

6: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 105 °C / Microwave irradiation

With sodium tungstate; potassium phosphate; dihydrogen peroxide; iodine; sodium hydride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1401348-61-5
2-(3-iodo-1H-indol-5-yl)-5-(methylthio)-1,3,4-thiadiazole

: 1401349-05-0
5-(3-(6-(4-chlorophenyl)pyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C

2: sodium tungstate; dihydrogen peroxide / water; acetic acid / 72 h / 20 °C

3: 1,4-dioxane / 20 - 100 °C

4: potassium phosphate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / 1,4-dioxane; water / 0.5 h / 105 °C

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 105 °C / Microwave irradiation

With sodium tungstate; potassium phosphate; dihydrogen peroxide; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;