N-acetyl-DL-homophenylalanine ethyl ester

Base Information

• Chemical Name: N-acetyl-DL-homophenylalanine ethyl ester
• CAS No.: 141289-30-7
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol file: 141289-30-7.mol

Synonyms:N-acetyl-DL-homophenylalanine ethyl ester

Chemical Property of N-acetyl-DL-homophenylalanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-acetyl-DL-homophenylalanine ethyl ester

There total 6 articles about N-acetyl-DL-homophenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.1%

2-Acetylamino-2-phenethyl-malonic acid monoethyl ester (80887-22-5) → N-acetyl-DL-homophenylalanine ethyl ester (141289-30-7)

Guidance literature:

In 1,4-dioxane; for 1.5h; Heating;

DOI:10.1080/10242430210706

Reference yield:

2-acetylamino-2-phenylethylmalonic acid diethyl ester (5463-92-3) → N-acetyl-DL-homophenylalanine ethyl ester (141289-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOH / ethanol / 2 h / 20 °C

1.2: 83.6 percent / HCl / H₂O; ethanol / pH 6 - 7

2.1: 86.1 percent / dioxane / 1.5 h / Heating

With sodium hydroxide; In 1,4-dioxane; ethanol;

DOI:10.1080/10242430210706

Reference yield:

2-acetylaminomalonic acid diethyl ester (1068-90-2) → N-acetyl-DL-homophenylalanine ethyl ester (141289-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium / ethanol / 0.67 h / 20 °C

1.2: 80.2 percent / ethanol / 5 h / Heating

2.1: NaOH / ethanol / 2 h / 20 °C

2.2: 83.6 percent / HCl / H₂O; ethanol / pH 6 - 7

3.1: 86.1 percent / dioxane / 1.5 h / Heating

With sodium hydroxide; sodium; In 1,4-dioxane; ethanol;

DOI:10.1080/10242430210706

upstream raw materials:

2-Acetylamino-2-phenethyl-malonic acid monoethyl ester

2-acetylamino-2-phenylethylmalonic acid diethyl ester

1-phenyl-2-bromoethane

2-acetylaminomalonic acid diethyl ester

Downstream raw materials:

(R)-2-Acetamido-4-phenylbutansaeure

(2S)-2-amino-4-phenyl-1-butanol

(+)-α-amino-4-phenylbutyric acid methyl ester hydrochloride

L-(+)-homophenylalanine hydrochloride