Benzenebutanoic acid, a-(acetylamino)-, (S)-

Base Information

• Chemical Name: Benzenebutanoic acid, a-(acetylamino)-, (S)-
• CAS No.: 96613-91-1
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol file: 96613-91-1.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, a-(acetylamino)-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanoic acid, a-(acetylamino)-, (S)-

There total 30 articles about Benzenebutanoic acid, a-(acetylamino)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-(acetylamino)-4-phenylbutanoic acid (5440-40-4) → D-homophenylalanine (943-73-7) + (2R)-N-acetyl-2-amino-4-phenylbutyric acid (5440-40-4,60505-02-4,96613-91-1,63393-59-9)

Guidance literature:

With L-aminoacylase; cobalt(II) chloride; In aq. buffer; at 20 - 38 ℃; for 1h; pH=7.5; enantioselective reaction; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

DOI:10.1021/acs.orglett.8b03910

Reference yield: 50.0%

2-(acetylamino)-4-phenylbutanoic acid (5440-40-4) → D-homophenylalanine (82795-51-5) + (R)-2-Acetamido-4-phenylbutansaeure (96613-91-1)

Guidance literature:

With D-aminoacylase; cobalt(II) chloride; In aq. buffer; at 20 - 38 ℃; for 5h; pH=7.5; enantioselective reaction; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

DOI:10.1021/acs.orglett.8b03910

Reference yield: 50.0%

N-acetyl-DL-homophenylalanine ethyl ester (141289-30-7) → (R)-2-Acetamido-4-phenylbutansaeure (96613-91-1) + N-acetyl-D-homophenylalanine ethyl ester

Guidance literature:

With water; In ethanol; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Microbiological reaction;

DOI:10.1016/j.tetasy.2010.02.011

upstream raw materials:

D-homophenylalanine

acetic anhydride

(+/-)-N-acetylhomophenylalanine methyl ester

N-acetyl-DL-homophenylalanine ethyl ester

Downstream raw materials:

D-homophenylalanine

L-(+)-homophenylalanine hydrochloride

(+)-α-amino-4-phenylbutyric acid methyl ester hydrochloride

(2S)-2-amino-4-phenyl-1-butanol