C₄₈H₇₂N₂O₉Si₂

Base Information

• Chemical Name: C₄₈H₇₂N₂O₉Si₂
• CAS No.: 1308253-75-9
• Molecular Formula: C₄₈H₇₂N₂O₉Si₂
• Molecular Weight: 877.279
• Mol file: 1308253-75-9.mol

Synonyms:C₄₈H₇₂N₂O₉Si₂

Chemical Property of C₄₈H₇₂N₂O₉Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₇₂N₂O₉Si₂

There total 12 articles about C₄₈H₇₂N₂O₉Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C48H74N2O9Si2 (1308253-71-5) → C48H72N2O9Si2 (1308253-75-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/jhet.609

Reference yield:

(S)-methyl-2-acetamido-3-(3-formyl-4-methoxy-3-methylphenyl)propanoate (1177255-27-4) → C48H72N2O9Si2 (1308253-75-9)

Guidance literature:

Multi-step reaction with 9 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 20 °C

2: hydrogenchloride; water / methanol / 10 h

3: lithium borohydride / tetrahydrofuran / 24 h

4: hydrogenchloride / methanol; water / 6 h / Reflux

5: acetic acid / dichloromethane; 2,2,2-trifluoroethanol / 9 h / -10 °C / Molecular sieve

6: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 - 20 °C

7: triethylamine; trifluoroacetic acid / dichloromethane / 24 h / 20 °C

8: formic acid / tetrahydrofuran; water / 2 h / 20 °C

9: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With hydrogenchloride; lithium borohydride; formic acid; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; Dess-Martin periodane; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; 2,2,2-trifluoroethanol; water; 1: Baeyer-Villiger oxidation;

DOI:10.1002/jhet.609

Reference yield:

(S)-methyl-2-acetamido-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoate (1177255-28-5) → C48H72N2O9Si2 (1308253-75-9)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium borohydride / tetrahydrofuran / 24 h

2: hydrogenchloride / methanol; water / 6 h / Reflux

3: acetic acid / dichloromethane; 2,2,2-trifluoroethanol / 9 h / -10 °C / Molecular sieve

4: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 0 - 20 °C

5: triethylamine; trifluoroacetic acid / dichloromethane / 24 h / 20 °C

6: formic acid / tetrahydrofuran; water / 2 h / 20 °C

7: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With hydrogenchloride; lithium borohydride; formic acid; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 2,2,2-trifluoroethanol; water;

DOI:10.1002/jhet.609

upstream raw materials:

(S)-methyl-2-acetamido-3-(3-formyl-4-methoxy-3-methylphenyl)propanoate

(S)-methyl-2-acetamido-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoate

C₁₃H₁₉NO₄

(1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol

Downstream raw materials:

C₃₆H₄₄N₂O₉