methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate

Base Information

Chemical Name:methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate
CAS No.:1313999-62-0
Molecular Formula:C₂₀H₂₈O₅
Molecular Weight:348.439
Hs Code.:

Synonyms:methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate

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Chemical Property of methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate

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Technology Process of methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate

There total 7 articles about methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1313999-61-9
5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

: 79-22-1
methyl chloroformate

: 1313999-62-0
methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate

Guidance literature:: 5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

methyl chloroformate; In hexane; at -78 - -5 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c1cc11919b

Reference yield:

: 1313999-67-5
1-(3,5-dimethoxybenzyloxy)-2,2,4,4-tetramethylpentan-3-one

: 1313999-62-0
methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 7 h / 20 °C / Cooling; Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

3.1: pyridine; sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.2: 4 h / -78 - -5 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; n-butyllithium; sulfuryl dichloride; potassium tert-butylate; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1039/c1cc11919b

Reference yield:

: 1313999-60-8
2-(2-bromo-3,5-dimethoxyphenyl)-3-tert-butyl-4,4-dimethyltetrahydrofuran-3-ol

: 1313999-62-0
methyl 2-(3-tert-butyl-4,4-dimethyl-4,5-dihydrofuran-2-yl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 - -5 °C / Inert atmosphere

With pyridine; n-butyllithium; sulfuryl dichloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c1cc11919b