5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

Base Information

Chemical Name:5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran
CAS No.:1313999-61-9
Molecular Formula:C₁₈H₂₅BrO₃
Molecular Weight:369.299
Hs Code.:

Synonyms:5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

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Chemical Property of 5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

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Technology Process of 5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

There total 6 articles about 5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1313999-60-8
2-(2-bromo-3,5-dimethoxyphenyl)-3-tert-butyl-4,4-dimethyltetrahydrofuran-3-ol

: 1313999-61-9
5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: With pyridine; sulfuryl dichloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c1cc11919b

Reference yield:

: 1313999-67-5
1-(3,5-dimethoxybenzyloxy)-2,2,4,4-tetramethylpentan-3-one

: 1313999-61-9
5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / dimethyl sulfoxide / 7 h / 20 °C / Cooling; Inert atmosphere

2: N-Bromosuccinimide / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

3: pyridine; sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; sulfuryl dichloride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1039/c1cc11919b

Reference yield:

: 705-76-0
3,5-dimethoxybenzyl alcohol

: 1313999-61-9
5-(2-bromo-3,5-dimethoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere

2.2: 5 h / 20 °C

3.1: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

4.1: potassium tert-butylate / dimethyl sulfoxide / 7 h / 20 °C / Cooling; Inert atmosphere

5.1: N-Bromosuccinimide / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

6.1: pyridine; sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; sulfuryl dichloride; potassium tert-butylate; phosphorus tribromide; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c1cc11919b