(3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid

Base Information

Chemical Name:(3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid
CAS No.:1202575-63-0
Molecular Formula:C₂₀H₁₉F₃O₅
Molecular Weight:396.363
Hs Code.:

Synonyms:(3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid

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Chemical Property of (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid

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Technology Process of (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid

There total 10 articles about (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1202577-70-5
Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

: 1202575-63-0
(3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid

Guidance literature:: Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate; With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

: 501334-19-6
methyl 3-[4-(tert-butyldimethylsilyloxybenzyl)phenyl]-3-oxopropanoate

: 1202575-63-0
(3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; formic acid / Noyori's catalyst / 0 - 35 °C / Inert atmosphere

2: silver(l) oxide / toluene / 20 - 110 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C

5: sodium hydroxide; water / methanol / 3 h / 20 °C

With formic acid; tetrabutyl ammonium fluoride; water; triethylamine; triphenylphosphine; sodium hydroxide; silver(l) oxide; diethylazodicarboxylate; Noyori's catalyst; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 251300-32-0
2-hydroxy-3-(trifluoromethyl)benzoic acid

: 1202575-63-0
(3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 15 h / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 20 - 70 °C

4: acetic anhydride; acetic acid / 2 h / 130 °C / Inert atmosphere

5: hydrogenchloride / water; methanol / 20 - 70 °C

6: sodium tetrahydroborate / methanol / 2 h / 20 °C

7: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C

8: sodium hydroxide; water / methanol / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; water; acetic anhydride; potassium carbonate; acetic acid; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;