Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

Base Information

Chemical Name:Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate
CAS No.:1202577-70-5
Molecular Formula:C₂₁H₂₁F₃O₅
Molecular Weight:410.39
Hs Code.:

Synonyms:Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

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Chemical Property of Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

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Technology Process of Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

There total 9 articles about Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501334-19-6
methyl 3-[4-(tert-butyldimethylsilyloxybenzyl)phenyl]-3-oxopropanoate

: 1202577-70-5
Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; formic acid / Noyori's catalyst / 0 - 35 °C / Inert atmosphere

2: silver(l) oxide / toluene / 20 - 110 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C

With formic acid; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; Noyori's catalyst; In tetrahydrofuran; toluene;

Reference yield:

: 1202577-54-5
Methyl (3S)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-3-hydroxypropionate

: 1202577-70-5
Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 3 steps

1: silver(l) oxide / toluene / 20 - 110 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

3: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C

With tetrabutyl ammonium fluoride; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; In tetrahydrofuran; toluene;

Reference yield:

: 251300-32-0
2-hydroxy-3-(trifluoromethyl)benzoic acid

: 1202577-70-5
Methyl (3S)-3-ethoxy-3-(4-{[7-(trifluoromethyl)-2,3-dihydro-1-benzofuran-3-yl]oxy}phenyl)propionate

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 15 h / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 20 - 70 °C

4: acetic anhydride; acetic acid / 2 h / 130 °C / Inert atmosphere

5: hydrogenchloride / water; methanol / 20 - 70 °C

6: sodium tetrahydroborate / methanol / 2 h / 20 °C

7: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; water; acetic anhydride; potassium carbonate; acetic acid; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;