(R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

Base Information

Chemical Name:(R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one
CAS No.:1192570-93-6
Molecular Formula:C₁₉H₂₅NO₂
Molecular Weight:299.413
Hs Code.:

Synonyms:(R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

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Chemical Property of (R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

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Technology Process of (R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

There total 9 articles about (R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 13540-76-6
3-(4-methoxyphenyl)prop-1-yne

: 1192570-63-0
5-isocyanato-2,4,4-trimethylpent-1-ene

: 1192570-96-9
(R)-5-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahyhydro-1H-indolizin-7-one

: 1192570-93-6
(R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

Guidance literature:: With chlorobis(ethylene)rhodium(I) dimer; O,O'-[(R)-3,3'-bis(trimethylsilyl)-1,1'-binaphthyl-2,2'-diyl]-N,N-dimethylphosphoramidite; In toluene; at 110 ℃; for 16h; enantioselective reaction; Inert atmosphere;
DOI:10.1055/s-0032-1316786

Reference yield:

: 13540-76-6
3-(4-methoxyphenyl)prop-1-yne

: 1192570-63-0
5-isocyanato-2,4,4-trimethylpent-1-ene

: (S)-5-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahyhydro-1H-indolizin-7-one

: 1192570-93-6
(R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

: (S)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

Guidance literature:: With chlorobis(ethylene)rhodium(I) dimer; O,O'-[(R)-3,3'-bis(trimethylsilyl)-1,1'-binaphthyl-2,2'-diyl]-N,N-dimethylphosphoramidite; In toluene; at 110 ℃; for 16h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja905065j

Reference yield:

: 13540-76-6
3-(4-methoxyphenyl)prop-1-yne

: 1192570-63-0
5-isocyanato-2,4,4-trimethylpent-1-ene

: (S)-5-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahyhydro-1H-indolizin-7-one

: 1192570-96-9
(R)-5-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahyhydro-1H-indolizin-7-one

: 1192570-93-6
(R)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

: (S)-7-(4-methoxybenzyl)-2,2,8a-trimethyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one

Guidance literature:: With O,O'-(R)-3,3'-di-tert-butyl-5,5',6,6'-tetramethyl-1,1'-biphenyl-2,2'-diyl-N,N-dimethylphosphoramidite; chlorobis(ethylene)rhodium(I) dimer; In toluene; at 110 ℃; for 16h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja905065j