1-NITRO-4-PROP-2-YN-1-YLBENZENE

Base Information

• Chemical Name: 1-NITRO-4-PROP-2-YN-1-YLBENZENE
• CAS No.: 13540-76-6
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Hs Code.: 2909309090
• Mol file: 13540-76-6.mol

Synonyms:1-METHOXY-4-(PROP-2-YN-1-YL)BENZENE;

Chemical Property of 1-NITRO-4-PROP-2-YN-1-YLBENZENE

Chemical Property:

• PSA: 9.23000
• LogP: 1.87090

Purity/Quality:

98%min ^*data from raw suppliers

1-Methoxy-4-prop-2-yn-1-ylbenzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-NITRO-4-PROP-2-YN-1-YLBENZENE

There total 21 articles about 1-NITRO-4-PROP-2-YN-1-YLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(3,3-Dibromo-2-propenyl)anisole → 3-(4-methoxyphenyl)prop-1-yne (13540-76-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran;

Reference yield: 92.0%

1-methoxy-4-(prop-1-yn-1-yl)benzene (2749-94-2) → 3-(4-methoxyphenyl)prop-1-yne (13540-76-6)

Guidance literature:

With n-butyllithium; In hexane; at 20 ℃;

DOI:10.1016/j.polymer.2013.10.050

Reference yield: 90.2%

(3-(4-methoxyphenyl)prop-1-ynyl)trimethylsilane (102987-40-6) → 3-(4-methoxyphenyl)prop-1-yne (13540-76-6)

Guidance literature:

With potassium carbonate; In methanol; at 0 ℃;

upstream raw materials:

1-bromo-4-methoxy-benzene

propargyl bromide

p-methoxybenzyl chloride

acetylenemagnesium bromide

Downstream raw materials:

1,5-bis(4-methoxyphenyl)pent-3-yn-2-one

C₁₇H₁₇N₃O

C₁₆H₁₅N₃O

1,3,5-tris[(4-methoxyphenyl)methyl]benzene

Refernces

• 1、 Becker,J.Y.. "-". . p. 247 - 252. Retrieved 1976.
• 2、 -. "Compound of dipyrrolopyridine structure Preparation method and medical application". Paragraph 0147; 0151-0153. . Retrieved 2021/08/25.
• 3、 Conesa-Milián, Laura,Falomir, Eva,Murga, Juan,Carda, Miguel,Marco, J. Alberto. "Novel multitarget inhibitors with antiangiogenic and immunomodulator properties". . p. 87 - 98. Retrieved 2019/03/19.