diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate

Base Information

• Chemical Name: diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate
• CAS No.: 864871-37-4
• Molecular Formula: C₁₉H₃₃NO₆
• Molecular Weight: 371.474
• Mol file: 864871-37-4.mol

Synonyms:diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate

Chemical Property of diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate

There total 3 articles about diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

di-tert-butyl (cyclohexylmethylene)dicarbamate + diethyl malonate (105-53-3) → diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate (864871-37-4)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 40 ℃; for 24h;

DOI:10.1002/anie.201300231

Reference yield: 82.0%

diethyl malonate (105-53-3) + tert-butyl cyclohexyl(phenylsulfonyl)methylcarbamate (253426-70-9) → diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate (864871-37-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 30 ℃; for 24h;

DOI:10.1080/00397910600602537

Reference yield:

diethyl malonate (105-53-3) + tert-butyl N-[cyclohexyl(p-tolylsulfonyl)methyl]carbamate (365441-86-7) → diethyl 2-(1-(N-tert-butoxycarbonylamino)-1-(cyclohexyl)-methyl)malonate (864871-37-4)

Guidance literature:

diethyl malonate; With sodium hydride; In tetrahydrofuran; cooling;

tert-butyl N-[cyclohexyl(p-tolylsulfonyl)methyl]carbamate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2005.04.077

upstream raw materials:

diethyl malonate

tert-butyl N-[cyclohexyl(p-tolylsulfonyl)methyl]carbamate

tert-butyl cyclohexyl(phenylsulfonyl)methylcarbamate

Downstream raw materials:

ethyl 3-amino-3-cyclohexylpropanoate hydrochloride

3-amino-3-cyclohexylpropanoic acid hydrochloride