12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester

Base Information

Chemical Name:12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester
CAS No.:173912-53-3
Molecular Formula:C₂₅H₄₀INO₈
Molecular Weight:609.499
Hs Code.:

Synonyms:12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester

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Chemical Property of 12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester

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Technology Process of 12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester

There total 4 articles about 12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 173912-52-2
12-((2-hydroxy-3-iodo-5-nitrobenzyl)oxy)dodecanoic acid ethyl ester

: 173912-53-3
12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 6h; Ambient temperature;
DOI:10.1021/jo951350k

Reference yield:

: 505-95-3
12-hydroxydodecanoic acid

: 173912-53-3
12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂SO₄ / 4 h / Heating

2: 85 percent / Ag₂O / CH₂Cl₂ / 48 h / Ambient temperature

3: 99 percent / benzyltrimethylammonium iododichloride, NaHCO₃ / CH₂Cl₂; methanol / 19 h / Ambient temperature

4: 80 percent / i-Pr₂NEt / CH₂Cl₂ / 6 h / Ambient temperature

With sulfuric acid; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In methanol; dichloromethane;
DOI:10.1021/jo951350k

Reference yield:

: 78640-13-8
12-hydroxydodecanoic acid ethyl ester

: 173912-53-3
12-[3-Iodo-2-(2-methoxy-ethoxymethoxy)-5-nitro-benzyloxy]-dodecanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Ag₂O / CH₂Cl₂ / 48 h / Ambient temperature

2: 99 percent / benzyltrimethylammonium iododichloride, NaHCO₃ / CH₂Cl₂; methanol / 19 h / Ambient temperature

3: 80 percent / i-Pr₂NEt / CH₂Cl₂ / 6 h / Ambient temperature

With sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In methanol; dichloromethane;
DOI:10.1021/jo951350k