Dodecanoic acid, 12-hydroxy-, ethyl ester

Base Information

• Chemical Name: Dodecanoic acid, 12-hydroxy-, ethyl ester
• CAS No.: 78640-13-8
• Molecular Formula: C14H28O3
• Molecular Weight: 244.37000
• Mol file: 78640-13-8.mol

Synonyms:12-hydroxydodecanoic acid ethyl ester;12-hydroxylauric acid ethyl ester;ethyl 12-hydroxydodecanoate;

Chemical Property of Dodecanoic acid, 12-hydroxy-, ethyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 3.44280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dodecanoic acid, 12-hydroxy-, ethyl ester

There total 7 articles about Dodecanoic acid, 12-hydroxy-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

12-hydroxydodecanoic acid (505-95-3) + ethanol (64-17-5) → 12-hydroxydodecanoic acid ethyl ester (78640-13-8)

Guidance literature:

With sulfuric acid; for 4h; Heating;

DOI:10.1021/jo951350k

Reference yield: 67.2%

1,12-dodecadicarboxylic acid monoethyl ester (66003-63-2) → 12-hydroxydodecanoic acid ethyl ester (78640-13-8)

Guidance literature:

With borane-THF; In tetrahydrofuran; at -10 - 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2016.05.027

Reference yield: 60.0%

methanol (67-56-1) + Ethyl 12-acetoxydodecanoate → methyl 12-hydroxydodecanoate (71655-36-2) + 12-hydroxydodecanoic acid ethyl ester (78640-13-8)

Guidance literature:

[t-Bu₂SnOH(Cl)]2; In tetrahydrofuran; at 0 ℃; for 20h;

DOI:10.1002/1521-3765(20010803)7:15<3321::AID-CHEM3321>3.0.CO;2-H

upstream raw materials:

12-hydroxydodecanoic acid

ethanol

methanol

ethyl bromide

Downstream raw materials:

monoethyl ester of dodecanedioic acid chloride

ethyl 12-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)dodecanoate

C₂₂H₃₁ClO₅

12-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)dodecanoic acid

Refernces

• 1、 Furumochi, Sachie,Onoda, Tatsuya,Cho, Yuko,Fuwa, Haruhiko,Sasaki, Makoto,Yotsu-Yamashita, Mari,Konoki, Keiichi. "Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid". supporting information. p. 2992 - 2996. Retrieved 2016/06/13.
• 2、 -. "Functionalised nanoparticles, their production and use". Page/Page column 10-13. . Retrieved 2014/09/03.