ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate

Base Information

• Chemical Name: ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate
• CAS No.: 872102-24-4
• Molecular Formula: C₁₆H₁₈N₂O₂S
• Molecular Weight: 302.397
• Mol file: 872102-24-4.mol

Synonyms:ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate

Chemical Property of ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate

There total 1 articles about ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-amino-3-methylthiophene-2-carboxylate (88796-28-5) + N-methyl benzimidoyl chloride (21737-87-1) → ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate (872102-24-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 0 ℃; Inert atmosphere;

DOI:10.1055/s-0033-1340959

Reference yield:

ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate (872102-24-4) → ethyl 4-bromo-3-methyl-5-(N'-methylbenzimidamido)thiophene-2-carboxylate (1609561-64-9)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 3h; Reflux;

DOI:10.1055/s-0033-1340959

Reference yield:

ethyl 3-methyl-5-(((methylamino)(phenyl)methylene)amino)thiophene-2-carboxylate (872102-24-4) → ethyl 1,6-dimethyl-2-phenyl-1H-thieno[2,3-d]imidazole-5-carboxylate (1609561-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / Reflux

2: potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide / N,N-dimethyl-formamide / 6 h / Reflux; Inert atmosphere

With N-Bromosuccinimide; copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1055/s-0033-1340959

upstream raw materials:

ethyl 5-amino-3-methylthiophene-2-carboxylate

N-methyl benzimidoyl chloride

Downstream raw materials:

ethyl 4-bromo-3-methyl-5-(N'-methylbenzimidamido)thiophene-2-carboxylate

ethyl 1,6-dimethyl-2-phenyl-1H-thieno[2,3-d]imidazole-5-carboxylate