ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Base Information

Chemical Name:ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate
CAS No.:1373840-64-2
Molecular Formula:C₂₅H₂₉BrN₄O₅S
Molecular Weight:577.499
Hs Code.:

Synonyms:ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

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Chemical Property of ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

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Technology Process of ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

There total 9 articles about ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 2969-81-5
Ethyl 4-bromobutyrate

: 1373839-55-4
2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2H-indazole-3-carboxamide

: 1373840-64-2
ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 3h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373840-64-2
ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice

2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

4.1: acetic acid / 60 °C

4.2: 0.08 h / 60 °C

5.1: phosphorus trichloride / chloroform / 1 h / 60 °C

6.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

7.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

8.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

10.1: potassium carbonate / acetonitrile / 3 h / 80 °C

With pyridine; sulfuric acid; water; nitric acid; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene; acetonitrile; 3.1: Suzuki Coupling;

Reference yield:

: 20357-20-4
5-bromo-2-nitrobenzaldehyde

: 1373840-64-2
ethyl4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

3.1: acetic acid / 60 °C

3.2: 0.08 h / 60 °C

4.1: phosphorus trichloride / chloroform / 1 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

6.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

7.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

9.1: potassium carbonate / acetonitrile / 3 h / 80 °C

With pyridine; sulfuric acid; water; nitric acid; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene; acetonitrile; 2.1: Suzuki Coupling;