phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Base Information

Chemical Name:phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate
CAS No.:1373840-73-3
Molecular Formula:C₂₉H₂₉BrN₄O₅S
Molecular Weight:625.543
Hs Code.:

Synonyms:phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

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Chemical Property of phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

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Technology Process of phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

There total 11 articles about phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1373840-66-4
4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoic acid

: 108-95-2,27073-41-2
phenol

: 1373840-73-3
phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373840-73-3
phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Guidance literature:: Multi-step reaction with 12 steps

1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice

2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

4.1: acetic acid / 60 °C

4.2: 0.08 h / 60 °C

5.1: phosphorus trichloride / chloroform / 1 h / 60 °C

6.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

7.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

8.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

10.1: potassium carbonate / acetonitrile / 3 h / 80 °C

11.1: water; lithium hydroxide / isopropyl alcohol; 1,4-dioxane / 1.5 h / 60 °C

11.2: 20 °C

12.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With pyridine; sulfuric acid; water; nitric acid; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; lithium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; 3.1: Suzuki Coupling;

Reference yield:

: 20357-20-4
5-bromo-2-nitrobenzaldehyde

: 1373840-73-3
phenyl 4-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}butanoate

Guidance literature:: Multi-step reaction with 11 steps

1.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

3.1: acetic acid / 60 °C

3.2: 0.08 h / 60 °C

4.1: phosphorus trichloride / chloroform / 1 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

6.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

7.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

9.1: potassium carbonate / acetonitrile / 3 h / 80 °C

10.1: water; lithium hydroxide / isopropyl alcohol; 1,4-dioxane / 1.5 h / 60 °C

10.2: 20 °C

11.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With pyridine; sulfuric acid; water; nitric acid; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; lithium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; 2.1: Suzuki Coupling;