5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol

Base Information

• Chemical Name: 5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol
• CAS No.: 1374218-22-0
• Molecular Formula: C₂₃H₂₂N₄O₃
• Molecular Weight: 402.453

Synonyms:5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol

Chemical Property of 5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol

Chemical Property:

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Technology Process of 5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol

There total 6 articles about 5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-ethyl-3-oxobutanoic acid (4433-85-6) + [4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide (1374218-14-0) → 5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol (1374218-22-0)

Guidance literature:

In ethanol; for 8h; Reflux;

DOI:10.1002/cjoc.201100256

Reference yield:

phthalic anhydride (85-44-9) → 5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol (1374218-22-0)

Guidance literature:

Multi-step reaction with 5 steps

1: aluminum (III) chloride

2: hydrazine hydrate / ethanol / 2 h / Reflux

3: potassium carbonate / acetone / 30 h / Reflux

4: hydrazine hydrate / ethanol / 2 h / Reflux

5: ethanol / 8 h / Reflux

With aluminum (III) chloride; potassium carbonate; hydrazine hydrate; In ethanol; acetone; 1: Friedel Crafts reaction;

DOI:10.1002/cjoc.201100256

Reference yield:

[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid ethyl ester (1374218-13-9) → 5-methyl-3-oxo-2-[1(2H)-oxo-4-(2,4,6-trimethylphenyl)phthalazin-2-ylmethylcarbonyl]-3,4-dihydropyrazol (1374218-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: ethanol / 8 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1002/cjoc.201100256

upstream raw materials:

phthalic anhydride

[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid ethyl ester

2-ethyl-3-oxobutanoic acid

[4-(2,4,6-trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

Downstream raw materials:

2-[(6-methyl-7H-pyrazolo[5,1-c][1,2,4]triazol-3-yl)methyl]-4-(2,4,6-trimethylphenyl) phthalazin-1(2H)-one

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