tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate

Base Information

• Chemical Name: tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate
• CAS No.: 1520053-13-7
• Molecular Formula: C₂₁H₂₅ClF₃N₅O₃
• Molecular Weight: 487.909

Synonyms:tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate

Chemical Property of tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate

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Technology Process of tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate

There total 2 articles about tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

tert-butyl 4-(4-amino-3-methoxy-phenyl)-piperazine-1-carboxylate (1246532-96-6) + 2,4-dichloro-5-trifluoromethylpyrimidine (3932-97-6) → tert-butyl-4-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-carboxylate (1383682-31-2) + tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate (1520053-13-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 20 ℃;

DOI:10.5012/bkcs.2013.34.10.3129

Reference yield:

tert-butyl 4-(4-amino-3-methoxy-phenyl)-piperazine-1-carboxylate (1246532-96-6) + 2,4-dichloro-5-trifluoromethylpyrimidine (3932-97-6) → tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate (1520053-13-7)

Guidance literature:

With potassium carbonate; In butan-1-ol; at 20 ℃;

Reference yield: 80.0%

1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one (1021426-42-5) + tert-butyl-4-(4-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl-amino)-3-methoxyphenyl)piperazin-1-carboxylate (1520053-13-7) → tert-butyl-4-(4-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-3-methoxyphenyl)piperazin-1-carboxylate

Guidance literature:

With hydrogenchloride; In 2-ethoxy-ethanol; at 50 ℃;

upstream raw materials:

tert-butyl 4-(4-amino-3-methoxy-phenyl)-piperazine-1-carboxylate

2,4-dichloro-5-trifluoromethylpyrimidine

Downstream raw materials:

C₂₃H₂₅F₃N₆O₂

C₂₃H₂₅F₃N₆O₂

C₂₄H₂₇F₃N₆O₃

C₂₅H₂₉F₃N₆O₄

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