1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone

Base Information

• Chemical Name: 1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone
• CAS No.: 1021426-42-5
• Molecular Formula: C13H19N3O2
• Molecular Weight: 249.313
• Mol file: 1021426-42-5.mol

Synonyms:1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone;1-[4-(4-amino-3-methoxyphenyl)piperazin-1-yl]ethan-1-one;4-(4-acetyl-1-piperazinyl)-2- (methyloxy)aniline;1-[4-(4-amino-3-methoxyphenyl)-1-piperazinyl]-Ethanone;2-Methoxy-4-(4-acetylpiperazin-1-yl)benzenamine

Chemical Property of 1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone

Chemical Property:

• Melting Point: 131 °C
• Boiling Point: 495.4±45.0 °C(Predicted)
• PKA: 7.63±0.10(Predicted)
• PSA: 58.80000
• Density: 1.185±0.06 g/cm3(Predicted)
• LogP: 1.53000

Purity/Quality:

99%, ^*data from raw suppliers

1-[4-(4-Amino-3-methoxyphenyl)piperazin-1-yl]ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone

There total 8 articles about 1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-{3-methoxy-4-nitrophenyl}piperazine-1-yl)ethan-1-one (1116229-11-8) → 1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one (1021426-42-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 5h;

DOI:10.3390/molecules25122914

Reference yield:

5-fluoro-2-nitrophenol (446-36-6) → 1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one (1021426-42-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 0.5 h / Inert atmosphere

1.2: 60 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 90 °C / Inert atmosphere

3.1: platinum(IV) oxide; hydrogen / ethanol / 3 h / 25 °C / 975.1 Torr

With platinum(IV) oxide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide; acetone;

DOI:10.1021/jm400822z

Reference yield:

4-fluoro-2-methoxy-1-nitrobenzene (448-19-1) → 1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one (1021426-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 90 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogen / ethanol / 3 h / 25 °C / 975.1 Torr

With platinum(IV) oxide; hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl acetamide;

DOI:10.1021/jm400822z

upstream raw materials:

1-(4-{3-methoxy-4-nitrophenyl}piperazine-1-yl)ethan-1-one

4-fluoro-2-methoxy-1-nitrobenzene

5-fluoro-2-nitrophenol

tert-butyl 4-(3-methoxy-4-nitrophenyl)piperazine-1-carboxylate

Downstream raw materials:

N-(4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)formamide

1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]piperazin-1-yl]ethanone

1-[4-[4-[[5-chloro-4-[7-(hydroxymethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-yl]amino]-3-methoxy-phenyl]piperazin-1-yl]ethanone

1-[4-[4-[[4-(8-aminoimidazo[1,2-a]pyridin-3-yl)-5-chloro-pyrimidin-2-yl]amino]-3-methoxy-phenyl]piperazin-1-yl]ethanone

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