α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

Base Information

Chemical Name:α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile
CAS No.:120352-47-8
Molecular Formula:C₂₅H₃₃N₃O₄
Molecular Weight:439.555
Hs Code.:

α-isopropyl-α-<3-<N-<3-(3-methoxyphenoxy)propyl>-N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

Synonyms:α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

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Chemical Property of α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

Chemical Property:

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Technology Process of α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

There total 4 articles about α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5558-29-2
3-methyl-2-phenyl-butyronitrile

: 120352-47-8
α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / NaNH₂ / tetrahydrofuran / 2 h / 60 °C

2: 93 percent / HNO₃/H₂SO₄ / 1 h / Ambient temperature

3: 83 percent / 2.5 h / 90 °C

4: 2.) NaBH₄ / 1.) MeOH, 1.5 h, reflux; 2.) MeOH, 0.5 h, RT

With sodium tetrahydroborate; sulfuric acid; nitric acid; sodium amide; In tetrahydrofuran;
DOI:10.1248/cpb.36.4103

Reference yield:

: 120353-04-0
α-(3-chloropropyl)-α-isopropyl-α-phenylacetonitrile

: 120352-47-8
α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / HNO₃/H₂SO₄ / 1 h / Ambient temperature

2: 83 percent / 2.5 h / 90 °C

3: 2.) NaBH₄ / 1.) MeOH, 1.5 h, reflux; 2.) MeOH, 0.5 h, RT

With sodium tetrahydroborate; sulfuric acid; nitric acid;
DOI:10.1248/cpb.36.4103

Reference yield:

: 120351-74-8
α-(3-chloropropyl)-α-isopropyl-α-(4-nitrophenyl)acetonitrile

: 120352-47-8
α-isopropyl-α-<3--N-methylamino>propyl>-α-(4-nitrophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 2.5 h / 90 °C

2: 2.) NaBH₄ / 1.) MeOH, 1.5 h, reflux; 2.) MeOH, 0.5 h, RT

With sodium tetrahydroborate;
DOI:10.1248/cpb.36.4103