5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Base Information

Chemical Name:5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
CAS No.:1285513-81-6
Molecular Formula:C₂₃H₂₅N₃O₃
Molecular Weight:391.47
Hs Code.:

Synonyms:5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

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Chemical Property of 5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Chemical Property:

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Technology Process of 5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

There total 7 articles about 5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 1285517-76-1
5-hydroxy-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

: 1285513-81-6
5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 - 115 ℃; Inert atmosphere;

Reference yield:

: 2150-46-1
Methyl 2,5-dihydroxybenzoate

: 1285513-81-6
5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 7 h / Reflux

2.1: Reflux

3.1: potassium hydroxide; water / ethanol / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0 - 115 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 100-39-0
benzyl bromide

: 1285513-81-6
5-{[2-(dimethylamino)ethyl]oxy}-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 7 h / Reflux

1.3: Reflux

2.1: potassium hydroxide; water / ethanol / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0 - 115 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetone; toluene;