2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

Base Information

• Chemical Name: 2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide
• CAS No.: 1258013-38-5
• Molecular Formula: C₃₂H₄₀N₈O₂S
• Molecular Weight: 600.788
• Mol file: 1258013-38-5.mol

Synonyms:2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

Chemical Property of 2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

There total 13 articles about 2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-91-5) → 2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide (1258013-38-5)

Guidance literature:

With trifluoroacetic acid; In water; at 20 ℃; for 0.166667h;

Reference yield:

2-butyl-6-hydroxypyrimidine-4-carboxylic acid (1344033-86-8) → 2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide (1258013-38-5)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 1 h / 105 °C

2: triethylamine / dichloromethane / 1.25 h

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

4: trifluoroacetic acid / water / 0.17 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In dichloromethane; water; dimethyl sulfoxide;

Reference yield:

6-(bromomethyl)-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine (925438-37-5) → 2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide (1258013-38-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 15 h / 20 °C

2: iron; ammonium chloride / water; isopropyl alcohol / 1.75 h / Reflux

3: triethylamine / dichloromethane / 1.25 h

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

5: trifluoroacetic acid / water / 0.17 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene;

upstream raw materials:

tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

2-butyl-6-hydroxypyrimidine-4-carboxylic acid

2-butyl-6-chloropyrimidine-4-carbonyl chloride