tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate
• CAS No.: 1344033-91-5
• Molecular Formula: C₄₂H₅₆N₈O₆S
• Molecular Weight: 801.023
• Mol file: 1344033-91-5.mol

Synonyms:tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

There total 12 articles about tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

tert-butyl 4-((2-(2-(2-butyl-6-chloropyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-90-4) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-91-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

2-butyl-6-hydroxypyrimidine-4-carboxylic acid (1344033-86-8) → tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-91-5)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 1 h / 105 °C

2: triethylamine / dichloromethane / 1.25 h

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; dimethyl sulfoxide;

Reference yield:

6-(bromomethyl)-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine (925438-37-5) → tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-91-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 15 h / 20 °C

2: iron; ammonium chloride / water; isopropyl alcohol / 1.75 h / Reflux

3: triethylamine / dichloromethane / 1.25 h

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene;

upstream raw materials:

sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

2-butyl-6-hydroxypyrimidine-4-carboxylic acid

2-butyl-6-chloropyrimidine-4-carbonyl chloride

6-(bromomethyl)-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine

Downstream raw materials:

2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide